| Cat.No.: | PE-3431 |
| Product Name: | Recombinant METTL21D (VCPKMT) protein |
| Product Overview: | Recombinant METTL21D (VCPKMT) protein was expressed in a baculovirus expression system as the full length human protein (accession number NP_078834.2) with an N-terminal FLAG-Tag. The molecular weight of the protein is 27 kDa. |
| Background: | METTL21D (Methyltransferase-Like Protein 21D), also known as VCPKMT (Valosin Containing Protein Lysine Methyltransferase), is a member of the Family 16 group of methyltransferases. It is responsible for the trimethylation of VCP (also called p97) on Lys 315. VCP is a highly conserved member of the AAA+-ATPases (ATPases associated with various activities) family, involved in several cellular pathways including protein degradation, endoplasmic reticulum-associated degradation, cell cycle regulation, membrane fusion and DNA damage response. Recently, it has been shown that VCPKMT is involved in cancer metastasis formation, but the physiological role of K315me3 in VCP has not been established and also the effect of K315me3 on the ATPase activity of VCP is not yet clear. |
| Applications: | Suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100, and 0.5 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| EL-0111 | Recombinant Human MEF2B Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0067 | MeCP2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0109 | Human MECP2 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0110 | Human MEN1 Knockout Cell Line 1bp insertion | Inquiry |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
