| Cat.No.: | PE-3418 |
| Product Name: | Recombinant NFκB1 p105 protein |
| Product Overview: | Recombinant NF:kappa;B1 / NFκB p105 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_003989.2) with an N-terminal FLAG tag. The molecular weight of the protein is 107.1 kDa. |
| Background: | NFκB1 (Nuclear Factor Kappa B Subunit 1), also known as NFKB1 or NF-kappa-B, is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. The 105 kD protein can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. It is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunitof the NF-kappa-B (NFKB) protein complex. NFKB1 is a homo- or heterodimeric complex formed by the Rel-like domaincontainingproteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFκB1/p105 also appears to occur post-translationally. |
| Applications: | Suitable for use in protein-protein interaction, in vitro transcription assay, binding assay. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPESNaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0201 | Recombinant Human NFKBIL2 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0294 | Wedelolactone | Inquiry |
| ◆ Antibodies | ||
| EAb-1896 | NFκB p100 Polyclonal Antibody | Inquiry |
| EAb-1903 | NFATC2 Polyclonal Antibody | Inquiry |
| EAb-1904 | NF-1B2 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| NF-1A | NF-1B2 | NFATC2 | NFKBIL2 |
| NFκB | NFκB1 | NFκB3 | p100 |
| p105 | p120 | p150 | |
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