| Cat.No.: | PE-3394 |
| Product Name: | Recombinant SSRP1 / FACT p80 protein |
| Product Overview: | Recombinant human SSRP1 / FACT p80 protein was expressed in a baculovirus expression system as the full length protein (accession number NP_003137.1) with an N-terminal FLAG tag. The molecular weight of the protein is 82.2 kDa. |
| Background: | SSRP1 (Structure Specific Recognition Protein 1), also known as FACT p80 (Facilitates Chromatin Transcription Complex 80 KDa Subunit), is a component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II). |
| Applications: | Suitable for use in the study of binding assay, inhibitor screening, and selectivity profiling |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100 and 0.5 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0067 | Recombinant Human SSRP1 293 Cell Lysate | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-0574 | Recombinant Human SSRP1, His-tagged | Inquiry |
| PE-0575 | Recombinant Chicken SSRP1 | Inquiry |
| PE-0576 | Recombinant Rat SSRP1 Protein | Inquiry |
| PE-0577 | Recombinant Rhesus monkey SSRP1 Protein, His-tagged | Inquiry |
| Related Gene / Proteins | |||
| p80 | SSBP4 | SSRP1 | Ssu72 |
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