| Cat.No.: | PE-3331 |
| Product Name: | Recombinant KAT6B / MORF (718-1008) protein |
| Product Overview: | Recombinant KAT6B / MORF (718-1008) protein that includes amino acids 718-1008 of human KAT6B protein (accession number NP_036462.2) was expressed in a baculovirus expression system and contains an N-terminal FLAG tag. The molecular weight of the protein is 35.7 kDa. This product is the catalytic domain of KAT6B protein. |
| Background: | KAT6B (Lysine Acetyltransferase 6B), also called as MOZ2, MORF or MYST4, is a histone acetyltransferase and component of the MOZ/MORF protein complex. It has a histone H3 acetyltransferase activity. In addition to its acetyltransferase activity, the encoded full length protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. So it may be involved in both positive and negative regulation of transcription. KAT6B is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of KAT6B gene and the CREBBP gene results in acute myeloid leukemias. It may also be involved in cerebral cortex development. |
| Applications: | Suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10% glycerol, 0.04% Triton X-100, 0.5 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0073 | Anacardic Acid | Inquiry |
| ◆ Antibodies | ||
| EAb-0073 | KAT8 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0083 | Human KAT2A Knockout Cell Line 1bp insertion | Inquiry |
| CL-0085 | Human KAT2B Knockout Cell Line 31bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0159 | Recombinant Human MYST2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| Kaiso | KANSL2 | KAP1 | KAT13A |
| KAT13D | KAT2A | KAT2B | KAT4 |
| KAT5 | KAT6A | KAT6B | KAT7 |
| KAT8 | KAT9 | MOF | MORC2 |
| MORC3 | MORF | MORF4L2 | MOZ |
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