| Cat.No.: | PE-3281 |
| Product Name: | CBP Bromodomain |
| Description: | Recombinant human CBP Bromodomain (CREB Binding protein, CREBBP, accession number Q92793, amino acids 1091 to 1190) containing an N-terminal GST tag, expressed in E. coli. CBP is an important regulator of cell function and serves to integrate a number of key cell signaling pathways. CBP contains intrinsic histone acetylatransferase (HAT) activity and serves as a co-activator for a large number of transcription factors. The bromodomain of CBP specifically recognizes a number of acetylated proteins, including histones and transcription factors. The CBP gene is mutated in Rubinestein-Taybi Syndrome, a rare developmental disorder. |
| Applications: | Recombinant CBP Bromodomain is useful for protein binding and screening experiments examining acetylated protein substrates. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 36 kDa |
| Species: | Human |
| Formulation: | 20 mM Tris-HCl pH 8.0, 200 mM NaCl, 1 mM DTT, 20% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0094 | C646 | Inquiry |
| BSM-0124 | EML-425 | Inquiry |
| BSM-0150 | I-CBP112 (Hydrochloride) | Inquiry |
| ◆ Research Kits | ||
| EKIT-0122 | CBP bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | ||
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