| Cat.No.: | PE-3258 |
| Product Name: | NSD2 / MMSET Catalytic Domain, Recombinant Human |
| Description: | NSD2 / MMSET Catalytic Domain, Recombinant Human (WHSC1, accession O96028, amino acids 959-1365), containing an N-terminal GST tag, expressed in E. coli. NSD2/MMSET is a SET-domain containing histone methyltransferase, catalyzing the dimethylation of histone H3 at lysine 36. NSD2/MMSET, an oncogene that is overexpressed in several cancers, is thought to drive pathogenesis of t(4;14) positive multiple myeloma. Recombinant NSD2/MMSET requires nucleosomal substrates for activity. |
| Applications: | NSD2 / MMSET Catalytic Domain, Recombinant Human NSD2 / MMSET Catalytic Domain, Recombinant Human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 0.5 - 2 µg NSD2 per reaction with HeLa or recombinant nucleosomes as a substrate is recommended. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 61 kDa |
| Species: | Human |
| Formulation: | 25 mM Tris pH 8.0, 150 mM NaCl, 1 mM DTT, 1 mM EDTA and 20% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0494 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0498 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0306 | Doxycycline (hyclate) | Inquiry |
| Related Gene / Proteins | |||
| MMP | MMSET | nsd1 | NSD2 |
| NSD3 | NSMCE2 | NSUN1 | NSUN2 |
| NSUN3 | NSUN4 | NSUN5 | NSUN6 |
| NSUN7 | |||
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