| Cat.No.: | PE-3256 |
| Product Name: | DOT1L Catalytic Domain, Recombinant Human |
| Description: | Recombinant human DOT1 protein, catalytic domain (DOT1L, KMT4, accession Q8TEK3, amino acids 1-472), containing an N-terminal GST tag, expressed in E. coli. DOT1 is a histone methyltransferase, catalyzing the methylation of histone H3 at lysine 79 on nucleosomal substrates. |
| Applications: | Recombinant DOT1L Catalytic Domain, human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 3-5 µg DOT1L per reaction with HeLa or recombinant nucleosomes as a substrate is recommended. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 85 kDa |
| Species: | Human |
| Formulation: | 100 mM Tris pH 8.0, 5 mM glutathione and 25% glycerol. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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