| Cat.No.: | PE-3177 |
| Product Name: | Trim33a-[PHD-BRD](His) |
| Description: | A member of the Tripartite Motif (TRIM) family of proteins, TRIM33a functions as an E3 ubiquitin protein ligase for SMAD4. The C-terminally located PHD-bromodomain reader cassette displays a high affinity for histone H3 N-terminal tails with unmodified lysine-4, trimethylated lysine-9 (H3K9me3, bound by PHD) and acetylated lysine-18 (H3K18Ac, bound by bromodomain). The biological roles of TRIM33 include tumor suppression in various tissues, regulation of ALC1 activity in the PARP-dependent DNA damage response, transcriptional regulation in hematopoiesis and regulation of TGF-ß signaling in stem cell differentiation. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 26.5 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v) |
| Accession#: | NM_015906 |
| Tag: | His |
| Protein Length: | 885-1091 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0018 | Danusertib (PHA-739358) | Inquiry |
| BSM-0021 | PF-03814735 | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0107 | Recombinant Human TRIM68 293 Cell Lysate | Inquiry |
| EL-0109 | Recombinant Human TRIP4 Lysate | Inquiry |
| EL-0115 | Recombinant Human TRIM24 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| TRA2A | TRAF4 | TRAF5 | TRAF6 |
| TRAK2 | TRBP | TRDMT1 | TREX1 |
| TRF2 | TRIM11 | TRIM13 | TRIM16 |
| TRIM17 | TRIM2 | TRIM21 | trim24 |
| TRIM26 | TRIM28 | TRIM3 | TRIM33 More > |
| TRIM34 | TRIM35 | TRIM36 | TRIM37 |
| TRIM38 | TRIM39 | TRIM4 | TRIM5 |
| TRIM55 | TRIM6 | TRIM63 | TRIM66 |
| TRIM68 | TRIM8 | TRIM9 | TRIML1 |
| TRIP4 | Tristetraprolin | TRIT1 | TrkA |
| TRMT2A | TRMT44 | TRMT5 | TRMT6 |
| TROVE2 | TRUB2 | TRX1 | TRβ1 |
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