| Cat.No.: | PE-3146 |
| Product Name: | BRDT-Tndm (His) |
| Description: | Human recombinant BRDT, tandem construct comprising bromodomains 1 and 2, expressed with an N-terminal His tag. BRDT, like other human members of the BET family of chromatin-binding proteins (BRD2, BRD3, BRD4), comprises two bromodomains, protein modules that bind epsilon-N-acetyllysine residues. Mouse BRDT-1 (BRDT bromodomain 1) can bind simultaneously to two acetyllysine residues and, among the multiply acetylated histone tails tested, had the highest affinity for a histone H4 peptide acetylated at lysines 5 and 8 (H4K5AcK8Ac). Expression of BRDT is testis-specific and deletion of the mouse BRDT-1 causes abnormal spermatid development and sterility. Human recombinant BRDT, tandem construct comprising bromodomains 1 and 2, expressed with an N-terminal His-tag. BRDT’s functions in spermiogenesis include roles in broad, programmatic regulation of gene expression, mRNA splicing, chromatin remodeling, meiosis, formation of the chromocenter and post-meiotic genome repackaging. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 44.0 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 150 mM NaCl, 1.0 mM TCEP, 10% glycerol (v/v) |
| Accession#: | NM_001726 |
| Tag: | His |
| Protein Length: | 21-383 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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