| Cat.No.: | PE-3145 |
| Product Name: | BRPF1a (His) |
| Description: | Human recombinant BRPF1a bromodomain (longer BRPF1 isoform, isoform 1). Relative to BRPF1b (BRPF1 Isoform 2), the BRRPF1a bromodomain contains a six amino acid insert, EVTELD, after residue 660. A scaffolding component of the MOZ/MORF histone acetyltransferase (HAT) complex and also an HBO1-BRPF1 HAT complex, native BRPF1b contains, in addition to its acetyllysine-binding bromodomain, two other presumed histone/chromatin binding domains, a PWWP domain and a PHD zinc-finger. The BRPF1 bromodomain binds multiple acetyllysines in histone N-terminal tails, with preference for H2AK5Ac, H4K12Ac and H3K14Ac. BRPF1 forms a complex with MOZ-TIF2 fusion proteins formed due to chromosomal translocations associated with acute myeloid leukemia (AML). Depletion of BRPF1 interferes with the MOZ-TIF2-driven transformation and upregulation of HOX gene expression, suggesting that BRPF1 could be a therapeutic target for AML. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 16.9 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v) |
| Accession#: | NM_001003694 |
| Tag: | His |
| Protein Length: | 627-746 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0001 | Bromodomain Non-Acetylated Ligand 4 | Inquiry |
| SP-0002 | Bromodomain Non-Acetylated Ligand 3 | Inquiry |
| SP-0003 | Bromodomain Non-Acetylated Ligand 1 | Inquiry |
| SP-0004 | Bromodomain Ligand 3 | Inquiry |
| SP-0006 | Bromodomain Ligand 4 | Inquiry |
| Related Gene / Proteins | |||
| BRCA1 | BRCA2 | BRCC3 | BRD |
| brd1 | brd2 | brd3 | brd4 |
| BRD7 | BRD8 | brd9 | brdt |
| BRL | BRM | BRMS1 | BRPF1 |
| BRPF2 | brpf3 | BRWD1 | BRWD3 |
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