| Cat.No.: | PE-3112 |
| Product Name: | BPTF-[BRD](GST) |
| Description: | Human recombinant BPTF bromodomain construct. Full-length BPTF1 is a DNA and histone-binding component of the NURF nucleosome remodeling complex. This construct comprises C-terminal bromodomain, which has binding affinity for various histone tail acetyllysines, including H4 K5Ac, K12Ac and K16Ac. BPTF expression is elevated in developing neurons, but also in neuronal tissue under various neurodegenerative conditions. Amplification of the BPTF-coding chromosomal locus is prevalent in various cancers and knockdown of BPTF can restrict proliferation in cultured cells with an engineered pre-malignant phenotype. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 42.2 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v) |
| Accession#: | NM_182641 |
| Tag: | GST |
| Protein Length: | 2791-2920 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0035 | Human BPTF Knockout Cell Line 8bp deletion | Inquiry |
| CL-0484 | Human BPTF Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0544 | BPTF/FALZ TR-FRET Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1698 | FALZ (BPTF), GST-tag | Inquiry |
| PE-1701 | FALZ (BPTF), His-tag | Inquiry |
| Related Gene / Proteins | |||
| BPTF | |||
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