| Cat.No.: | PE-3092 |
| Product Name: | BAZ1B (His) |
| Description: | Human recombinant BAZ1B bromodomain. BAZ1B (WSTF) is a key subunit of several ATP-dependent chromatin remodeling complexes with activities in nucleosome and chromatin assembly, in transcriptional regulation (at vitamin D-receptor (VDR) target genes) and in DNA replication and repair. The full-length protein comprises multiple domains, including the N-terminal domain which confers the atypical tyrosine kinase activity responsible for H2A.X Tyr142 phosphorylation, a key regulatory mark in the DNA damage response. The BAZ1B bromodomain displays affinity for several acetylated histone tail peptides, particularly ones incorporating H3K14(Ac). Interaction between BAZ1B and the gene promoter for the vitamin D synthetic enzyme 25(OH)D3 1a-hydroxylase, most likely mediated by bromodomain binding to acetylated histones, is necessary for ligand-dependent transcriptional repression by VDR. By virtue of its regulatory role in aromatase gene expression, BAZ1B may hold potential as a target for therapy in estrogen-dependent breast cancer. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 17.1 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris HCl, pH 7.5, 500 mM NaCl, 1 mM TCEP, 10% glycerol (v/v) |
| Accession#: | NM_032408 |
| Tag: | His & Strep |
| Protein Length: | 1340-1457 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0024 | Human BAP1 Knockout Cell Line 109bp insertion | Inquiry |
| CL-0030 | Human BAZ1A Knockout Cell Line 11bp deletion | Inquiry |
| CL-0031 | Human BAZ1B Knockout Cell Line 10bp deletion | Inquiry |
| CL-0032 | Human BAZ2A Knockout Cell Line 16bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0032 | Recombinant Human BAZ2B Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| BAF53A | BAP1 | BAP18 | BARD1 |
| BarX2 | BASP1 | BATZFD | BAZ1A |
| BAZ1B | BAZ2 | ||
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