| Cat.No.: | PE-3067 |
| Product Name: | SIRT1 |
| Description: | SIRT1 is the closest human homolog of yeast Sir2 (Silent information regulator 2), the founding exemplar of the ”sirtuins” or class III (NAD+-dependent) histone deacetylases (HDACs). The wide array of in vivo targets for SIRT1 deacetylation includes other proteins involved in regulatory post-translational modifications, several histone sites (H4K16, H3K9/K14, H1K26), multiple transcription factors (e.g. p53, NF-kB, FOXOs, PGC-1a) and key metabolic enzymes. SIRT1 has regulatory roles in gene expression and gene silencing, in cellular stress responses (e.g to DNA damage, oxidation and heat), in autophagy, in apoptosis and cell survival and in the circadian clock. SIRT1 activity is upregulated in response to calorie restriction (CR), in part by increased expression, in part by the elevation of cellular NAD+, and is required for downstream CR effects. Given the benefits of CR for the diseases of aging (and possibly longevity per se), the discovery of natural (e.g. resveratrol) and synthetic small molecule SIRT1 activators opened a promising avenue for therapeutic interventions in, for example, type 2 diabetes and neurodegeneration. While the question of whether these compounds act by directly stimulating SIRT1 catalytic activity has been controversial for some years, recent results indicate that this is most likely in fact the case and that activators bind an allosteric site on SIRT1. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 83.2 kDa |
| Species: | Human |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl pH 7.5, 100 mM NaCl, 10% glycerol (v/v). |
| Accession#: | NM_012238 |
| Tag: | His |
| Protein Length: | 1-747 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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