| Cat.No.: | PE-3053 |
| Product Name: | SUV39H1 Methyltransferase |
| Description: | A SET-domain lysine-methyltransfersase, SUV39H1’s activity is the major source of the transcriptionally repressive modification, H3K9me3, in heterochromatin. The oncoprotein Evi1, which is inappropriately expressed in AML (acute myeloid leukemia) and MDS (myelodysplastic syndrome), recruits SUV39H1, thus enhancing its transcription repressing activity. Depletion of SUV39H1 by shRNA or inhibition with chaetocin induced reexpression of silenced AML tumour suppressor genes, consistent with its potential as a therapeutic target. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 99.5 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 137 mM NaCl, 5 mM MgCl2, 4 mM DTT, 20% (v/v) glycerol |
| Accession#: | NM_003173 |
| Tag: | His |
| Protein Length: | 44-412 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0020 | Suz12 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0100 | Chaetocin | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0103 | Recombinant Human SUZ12 293 Cell Lysate | Inquiry |
| EL-0132 | Recombinant Human SUV39H1 293 Cell Lysate | Inquiry |
| EL-0137 | Recombinant Human SUV420H1 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| SUDS3 | SUMO | SUMO1 | SUMO2 |
| SUMO3 | SUN1 | Surf6 | suv39h1 |
| SUV39H2 | SUV3L1 | SUV420H1 | SUV420H2 |
| SUZ12 | |||
USA
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