| Cat.No.: | PE-3048 |
| Product Name: | PRMT4 Methyltransferase |
| Description: | PRMT4 (CARM1), a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an w-nitrogen of the guanidino function of protein L-arginine residues and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). PRMT4 methylates Arg-17 of histone H3, promoting active transcription. Other PRMT4 substrates include p300, multiple RNA-binding proteins and splicing factors. PRMT4 acts as a coactivator for various transcription factors, either by binding them directly or, in the case of nuclear receptors, via its interaction with p160 coactivators such as GRP1. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 91.7 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM HEPES/NaOH, pH 7.1, 180 mM NaCl, 2 mM DTT, 10% (v/v) glycerol. |
| Accession#: | NM_199141 |
| Tag: | GST |
| Protein Length: | 2-608 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0008 | PRMT4 peptide substrate, Biotin-labeled | Inquiry |
| ◆ Cell Lines | ||
| CL-0050 | Human CARM1 Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0123 | Ellagic acid | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0134 | Recombinant Human CARM1 293 Cell Lysate | Inquiry |
| EL-0148 | Recombinant Human CAMTA2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| CABIN1 | CAF1 | CAMKIV | CAMTA2 |
| CAPNS2 | CARHSP1 | CARM1 | CASC3 |
| CASP | CASP1 | CASP3 | |
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