PRMT8 Methyltransferase

Cat.No.:	PE-3041
Product Name:	PRMT8 Methyltransferase
Description:	PRMT8, a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an w-nitrogen of the guanidino function of protein L-arginine residues (w-monomethylation) and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). Although highly homologous (>80% identity) to the major arginine methyltransferase PRMT1, distinctive characteristics of PRMT8 include a unique, regulatory 76 residue N-terminal domain and its brain-specific expression, especially enhanced in the cortex. Although transfected GFP-PRMT8 can be myristoylated and localized to the plasma membrane, other evidence suggests that the endogenous, central nervous system PRMT8 is a nuclear protein. Removal of the N-terminal 60 amino acids of PRMT8 has been shown to dramatically enhance PRMT8 catalytic activity.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	43.2 kDa
Formulation:	Solution of purified recombinant protein in 50 mM Tris/HCl, pH 7.5, 125 mM NaCl, 1 mM TCEP, 10% (v/v) glycerol
Accession#:	NM_019854
Tag:	His
Protein Length:	61-394
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

Online Inquiry

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Products