SET1B Complex (5-subunits)

Cat.No.:	PE-3040
Product Name:	SET1B Complex (5-subunits)
Description:	SET1B Complex is a complex catalyzing the transcription-activating methylation of histone H3 lysine-4 and comprising a catalytic, SET domain-containing subunit, SET1B (SETD1B), plus the subunits of an activity-enhancing sub-complex—WDR5, RbBP5, Ash2L and DPY-30 (2 copies). In contrast to the H3K4-methylating activities of other MLL/SET1 family members that are more narrowly focused (e.g. MLL1 and MLL2 and the HOX genes), human SET1-containing complexes (SET1A and SET1B) appear to be responsible for widespread H3K4 trimethylation. However, the subnuclear localizations of SET1A and SET1B appear to overlap very little, suggesting that they may regulate different sets of genes.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	249.0 kDa
Species:	Human
Formulation:	Solution of purified recombinant proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl.
Accession#:	NM_015048, NM_017588, NM_005057, NM_001105214, NM_0325742
Tag:	His & GST
Protein Length:	SET1B 1629-1923 (C-term.), WDR5 22-334 (C-term.), RbBP5 1-538 (C-term.), Ash2L 2-534 (C-term.), DPY-30 1-99 (C-term.)
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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