SET7/9 Methyltransferase

Cat.No.:	PE-3039
Product Name:	SET7/9 Methyltransferase
Description:	SET7/9 (SETD7) is a SET domain-containing histone (lysine) methyltransferase, specific for monomethylation. SET7/9 was originally described as a histone H3 lysine-4 (H3K4) monomethyltransferase. While it does produce this mark (H3K4me) in vitro with peptide substrates or recombinant histone H3, its activity with nucleosomes is poor. Recent work has shown SET7/9 to function in the regulation and methylation of multiple non-histone regulatory factors including p53, p65, pRB,TAF10, SIRT1, DNMT1, the androgen receptor (AR), the farnesoid X receptor (FXR) and estrogen receptor a (ER). SET7/9 action as a coactivator for AR and its promotion of androgen-dependent cell proliferation suggests it as a potential target for prostate cancer therapy.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	68.5 kDa
Formulation:	Solution of purified recombinant protein in 50 mM Tris/HCl, pH 8.0, 500 mM NaCl, 10% (v/v) glycerol, 2 mM TCEP.
Accession#:	NM_030648
Tag:	GST & His
Protein Length:	2-366 (C-term.)
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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