| Cat.No.: | PE-3034 |
| Product Name: | NSD3 Methyltransferase |
| Description: | NSD3 (WHSC1L1) is a SET-domain lysine methyltransferase thought to primarily methylate H3K36, a mark associated with gene activation, although activities at H3K4 and H3K27 have also been reported. NSD3 forms a complex with bromodomain protein 4 (Brd4) where it functions in transcriptional activation. Both proteins are required for H3K36 trimethylation (H3K36me3) in the gene bodies of Brd4 targets. NSD3 is overexpressed in significant subsets of human lung and breast cancers and is considered a promising target for the development of anti-cancer therapies. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 66.7 kDa |
| Formulation: | Solution of purified recombinant protein in 50 mM Tris/HCl pH 8.0, 125 mM NaCl, 3 mM DTT, 10% glycerol (v/v). |
| Accession#: | NM_023034 |
| Tag: | GST |
| Protein Length: | 1021-1322 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0494 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0498 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0502 | NSD2 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | |
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