PRMT3 Methyltransferase

Cat.No.:	PE-3031
Product Name:	PRMT3 Methyltransferase
Description:	PRMT3, a type I arginine methyltransferase, catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to an omega-nitrogen of the guanidino function of protein L-arginine residues and the transfer of a second methyl group to the same nitrogen, yielding asymmetric dimethylarginine (aDMA). The tumor suppressor DAL-1/4.1B binds PRMT3 and inhibits its activity. DAL-1/4.1B’s capacity to induce apoptosis in the MCF-7 breast cancer cell line is enhanced by elevating cellular levels of the methyltransferase product/inhibitor S-adenosylhomocysteine, suggesting PRMT3 as a potential target for anti-cancer therapeutics.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	62.0 kDa
Formulation:	Solution of purified recombinant protein in 50 mM HEPES/KOH, pH 7.6, 100 mM KCl, 3 mM DTT, 30% (w/v) glycerol.
Accession#:	NM_005788
Tag:	His
Expression System:	E. coli
Protein Length:	2-531 (C-term.)
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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