| Cat.No.: | PE-3025 |
| Product Name: | MLL1 Complex |
| Description: | MLL1 Complex is a complex catalyzing the transcription-activating methylation of histone H3 lysine-4 and comprising a catalytic, SET domain-containing subunit, MLL1, plus the subunits of an activity-enhancing sub-complex—WDR5, RbBP5, Ash2L and DPY-30 (2 copies). MLL1 gene rearrangements that include the SET domain (partial tandem duplications) occur in 5-10% of acute myeloid leukemias (AMLs) and wild-type MLL1 can also be required for leukemic transformation by MLL1 fusion proteins, suggesting inhibition of MLL1 methyltransferase activity as a strategy for anti-leukemia therapy. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 212.0 kDa |
| Formulation: | Solution of purified recombinant proteins in 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 1 mM TCEP (tris(2-carboxyethyl)phosphine HCl), 10% (w/v) glycerol, 1 µM ZnCl. |
| Accession#: | NM_005933, NM_017588, NM_005057, NM_001105214, NM_0325742 |
| Tag: | His |
| Protein Length: | MLL1 3745-3969 (C-term.), WDR5 22-334 (C-term.), RbBP5 1-538 (C-term.), Ash2L 2-534 (C-term.), DPY-30 1-99 (C-term.) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0170 | MI-3 | Inquiry |
| BSM-0187 | OICR-9429 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0172 | Human KMT2C / MLL3 peptide | Inquiry |
| ◆ Research Kits | ||
| EKIT-0285 | MLL1 Complex Chemiluminescent Assay Kit | Inquiry |
| EKIT-0286 | MLL1 SAM-Screener Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| MLH1 | MLL | mll1 | MLL2 |
| MLL3 | MLL4 | MLL5 | MLLT1 |
| MLLT3 | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
