Recombinant Human HMGN1 protein

Cat.No.:	PE-2944
Product Name:	Recombinant Human HMGN1 protein
Background:	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
Applications:	ELISA; SDS-PAGE; Western blot
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Appearance:	Liquid
Molecular Weight:	37 kDa
Species:	Human
Formulation:	pH: 8.00; Constituents: 0.79% Tris HCl, 0.31% Glutathione. Note: Glutathione is reduced
Accession#:	P05114
Alternative Names:	FLJ27265/FLJ31471/High mobility group (nonhistone chromosomal) protein 14
Tag:	GST
Amino Acid Sequence:	MPKRKVSSTEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDKSSDKKV QTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
Sequence Similarities:	Belongs to the HMGN family.
Expression System:	Wheat germ
Post Translational Modifications:	Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Protein Length:	Full length protein; 1 to 100
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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