| Cat.No.: | PE-2456 |
| Product Name: | Recombinant Human YB1 protein |
| Background: | Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation. |
| Applications: | SDS-PAGE; Mass Spectrometry |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 38 kDa including tags |
| Purity: | > 85 % SDS-PAGE. Purified using conventional chromatography. |
| Species: | Human |
| Formulation: | pH: 7.4; Constituents: 80% PBS, 20% Glycerol |
| Accession#: | P67809 |
| Alternative Names: | BP 8/CBF-A/CCAAT binding transcription factor I subunit A |
| Tag: | His |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSEAET QQPPAAPPAA PALSAADTKP GTTGSGAGSG GPGGLTSAAP AGGDKKVIAT KVLGTVKWFN VRNGYGFINR NDTKEDVFVH QTAIKKNNPR KYLRSVGDGE TVEFDVVEGE KGAEAANVTG PGGVPVQGSK YAADRNHYRR YPRRRGPPRN YQQNYQNSES GEKNEGSESA PEGQAQQRRP YRRRRFPPYY MRRPYGRRPQ YSNPPVQGEV MEGADNQGAG EQGRPVRQNM YRGYRPRFRR GPPRQRQPRE DGNEEDKENQ GDETQGQQPP QRRYRRNFNY RRRRPENPKP QDGKETKAAD PPAENSSAPE AEQGGAE |
| Sequence Similarities: | Contains 1 CSD (cold-shock) domain. |
| Expression System: | E. coli |
| Post Translational Modifications: | Ubiquitinated by RBBP6; leading to a decrease of YBX1 transcativational ability.In the absence of phosphorylation the protein is retained in the cytoplasm.Cleaved by a 20S proteasomal protease in response to agents that damage DNA. Cleavage takes place in the absence of ubiquitination and ATP. The resulting N-terminal fragment accumulates in the nucleus. |
| Protein Length: | Full length protein; 1 to 324 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0175 | Human YB1 peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-0417 | YBX1 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-2456 | Recombinant Human YB1 protein | Inquiry |
| PE-2478 | Recombinant Human MSY2/YBOX2/YBX2 protein | Inquiry |
| Related Gene / Proteins | |||
| YB1 | YBOX2 | YBX1 | YBX2 |
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