| Cat.No.: | PE-2313 |
| Product Name: | Recombinant human HDAC6 (mutated H611 A) protein (Active) |
| Background: | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. |
| Applications: | Functional Studies; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 161 kDa including tags |
| Purity: | >79 % SDS-PAGE. Purified by affinity chromatography and gel filtration. |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.79% Tris HCl, 0.03% DTT, 0.38% Potassium chloride, 0.79% Sodium chloride, 0.06% EDTA, 10% Glycerol |
| Accession#: | Q9UBN7 |
| Alternative Names: | CPBHM/FLJ16239/HD 6 |
| Tag: | GST |
| Amino Acid Sequence: | MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDPMGHHHHHHGRRRASVAAGILVPRGSPGLD GIYARGIQMTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPR SIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDE QLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELM LVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVL RLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKH RIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNW STTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVA AGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALA EGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRST ETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNH CNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSA EYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEA VLSGEVLNGAAVVRPPGHAAEQDAACGFCFFNSVAVAARHAQTISGHALR ILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIG RAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFD AARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMA ACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDR EGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEEST PGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEA VGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQ TTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTP QISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLM QGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQEN WVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHH QALLDVKNIAHQNKFGEDMPHPH |
| Sequence Similarities: | Belongs to the histone deacetylase family. HD type 2 subfamily.Contains 1 UBP-type zinc finger. |
| Expression System: | Baculovirus |
| Post Translational Modifications: | Ubiquitinated. Its polyubiquitination however does not lead to its degradation.Sumoylated in vitro. |
| Protein Length: | Full length protein; 1 to 1215 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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