| Cat.No.: | PE-2248 |
| Product Name: | Recombinant human WHSC1/NSD2 protein (Catalytic domain) |
| Background: | Probable histone methyltransferase (By similarity). May act as a transcription regulator that binds DNA and suppresses IL5 transcription. |
| Applications: | Functional Studies; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 62 kDa including tags |
| Purity: | >82 % SDS-PAGE. |
| Species: | Human |
| Formulation: | pH: 8.5; Constituents: 0.79% Tris HCl, 1.74% Sodium chloride, 0.08% DTT, 0.31% Glutathione, 10% Glycerol |
| Accession#: | O96028 |
| Alternative Names: | FLJ23286/IL5 promoter REII region binding protein/KIAA1090 |
| Tag: | GST |
| Amino Acid Sequence: | MSPILGYWKIKGLVQPTRLLLEYLEEKYEEHLYERDEGDKWRNKKFELGL EFPNLPYYIDGDVKLTQSMAIIRYIADKHNMLGGCPKERAEISMLEGAVL DIRYGVSRIAYSKDFETLKVDFLSKLPEMLKMFEDRLCHKTYLNGDHVTH PDFMLYDALDVVLYMDPMCLDAFPKLVCFKKRIEAIPQIDKYLKSSKYIA WPLQGWQATFGGGDHPPKSDLEVLFQGPLGSEGDRGSRYQGVRGIGRVFK NALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTAD ISEIPKCNCKPTDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTK RQYPETKIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHA HENDITHFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDT RVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSGFLGDRPKTS TTLSSEEKGKKTKKKTRRRRAKGEGKRQSED |
| Sequence Similarities: | Belongs to the histone-lysine methyltransferase family. SET2 subfamily.Contains 1 AWS domain.Contains 1 HMG box DNA-binding domain.Contains 4 PHD-type zinc fingers.Contains 1 post-SET domain.Contains 2 PWWP domains.Contains 1 SET domain. |
| Expression System: | E. coli |
| Post Translational Modifications: | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| Protein Length: | Protein fragment; 941 to 1240 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| CL-0222 | Human WHSC1L1 Knockout Cell Line 10bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0127 | Recombinant Human WHSC1L1 293 Cell Lysate | Inquiry |
| EL-0128 | Recombinant Human WHSC1L1 293 Cell Lysate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | WHSC1 |
| WHSC1L1 | |||
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