| Cat.No.: | PE-2147 |
| Product Name: | Recombinant Human COP1 protein |
| Background: | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1. |
| Applications: | Western blot; ELISA |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Alternative Names: | Constitutive photomorphogenesis protein 1 homolog/COP/E3 ubiquitin-protein ligase RFWD2 |
| Tag: | GST |
| Amino Acid Sequence: | CLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFD TVKSVLDKDRKEDDTNEFVSAVCWRALPDGESNVLIAANSQGTIKVLELV |
| Sequence Similarities: | Belongs to the COP1 family.Contains 1 RING-type zinc finger.Contains 7 WD repeats. |
| Expression System: | Wheat germ |
| Protein Length: | Protein fragment; 632 to 731 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0033 | Human COMMD3-BMI1 Knockout Cell Line | Inquiry |
| CL-0262 | Human COPS6 Knockout Cell Line 40bp deletion | Inquiry |
| CL-0271 | Human COPS7A Knockout Cell Line 2bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0212 | Recombinant Human C17orf79 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0278 | Entacapone | Inquiry |
| Related Gene / Proteins | |||
| COMMD2 | COMMD3 | COMMD4 | COMMD6 |
| COMMD9 | COMT | COP1 | COPRS |
| COPS6 | COPS7A | COPS7B | CoREST |
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