| Cat.No.: | PE-2146 |
| Product Name: | Recombinant Human E3 SUMO-protein ligase PIAS4/PIASy |
| Background: | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. |
| Applications: | Western blot; ELISA |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Alternative Names: | E3 SUMO protein ligase PIAS4/E3 SUMO-protein ligase PIAS4/FLJ12419 |
| Tag: | GST |
| Amino Acid Sequence: | MAAELVEAKNMVMSFRVSDLQMLLGFVGRSKSGLKHELVTRALQLVQFDC SPELFKKIKELYETRYAKKNSEPAPQPHRPLDPLTMHSTYDRAGAVPRTP LAGPNIDYPVLYGKYLNGLGRLPAKTLKPEVRLVKLPFFNMLDELLKPTE LVPQNNEKLQESPCIFALTPRQVELIRNSRELQPGVKAVQVVLRICYSDT SCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEPKRPCRPINLTHLMY LSSATNRITVTWGNYGKSYSVALYLVRQLTSSELLQRLKTIGVKHPELCK ALVKEKLRLDPDSEIATTGVRVSLICPLVKMRLSVPCRAETCAHLQCFDA VFYLQMNEKKPTWMCPVCDKPAPYDQLIIDGLLSKILSECEDADEIEYLV DGSWCPIRAEKERSCSPQGAILVLGPSDANGLLPAPSVNGSGALGSTGGG GPVGSMENGKPGADVVDLTLDSSSSSEDEEEGEEEEEDEDEEGPRPKRRC PFQKGLVPAC |
| Sequence Similarities: | Belongs to the PIAS family.Contains 1 PINIT domain.Contains 1 SAP domain.Contains 1 SP-RING-type zinc finger. |
| Expression System: | Wheat germ |
| Post Translational Modifications: | Sumoylated. Lys-35 is the main site of sumoylation. Sumoylation is required for TCF4 sumoylation and transcriptional activitation. Represses LEF1 transcriptional activity. SUMO1 is the preferred conjugate. |
| Protein Length: | Full length protein; 1 to 510 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0053 | PIM1 Polyclonal Antibody | Inquiry |
| EAb-0326 | PIM1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0200 | Quercetin, Dihydrate | Inquiry |
| BSM-0223 | SMI-4a | Inquiry |
| BSM-0271 | CUDC-907 | Inquiry |
| Related Gene / Proteins | |||
| PI3K | PIAS2 | PIAS4 | PIASy |
| PID | PIM | PIM1 | PIM1 |
| PIM2 | PITX2 | PiwiL2 | PIWIL4 |
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