| Cat.No.: | PE-2084 |
| Product Name: | Recombinant human PARP3/IRT1 protein |
| Background: | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. |
| Applications: | Functional Studies; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.0462% DTT, 0.395% Tris HCl, 0.05% Tween, 50% Glycerol, 0.58% Sodium chloride |
| Alternative Names: | ADP ribosyltransferase (NAD+; poly (ADP ribose)/ADP ribosyltransferase diphtheria toxin like 3/ADPRT-3 |
| Sequence Similarities: | Contains 1 PARP alpha-helical domain.Contains 1 PARP catalytic domain. |
| Expression System: | Sf9 Insect Cells |
| Post Translational Modifications: | Auto-poly(ADP)-ribosylation. |
| Protein Length: | Full length protein |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0059 | PARP Monoclonal Antibody | Inquiry |
| EAb-0061 | PARP Polyclonal Antibody | Inquiry |
| EAb-0062 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0063 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0064 | Paf1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| IRF-2 | IRF-3 | IRF-4 | IRF-5 |
| IRT1 | PABPC1L2A | PABPC5 | PABPN1 |
| PAD | PAD1 | PAD2 | PAD3 |
| PAD4 | PADI1 | PADI2 | PADI3 |
| PADI4 | PADI6 | PAF1 | PAN2 More > |
| PAPD1 | PAPD4 | PAPD5 | PAPD7 |
| PAPOLA | PAPOLB | PARD6A | PARG |
| PARK2 | PARK7 | PARP | PARP1 |
| PARP10 | PARP11 | PARP12 | PARP14 |
| PARP15 | PARP16 | PARP2 | PARP3 |
| PARP4 | PARP6 | PARP7 | PARP8 |
| PARP9 | PAX5 | PAX6 | PAX7 |
| PAX9 | |||
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