| Cat.No.: | PE-2058 |
| Product Name: | Recombinant Human TIP49A protein |
| Background: | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.May be able to bind plasminogen at cell surface and enhance plasminogen activation.Essential for cell proliferation. |
| Applications: | Mass Spectrometry; SDS-PAGE |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 52 kDa including tags |
| Purity: | > 95 % SDS-PAGE. Purified using conventional chromatography techniques. |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.077% DTT, 0.316% Tris HCl, 20% Glycerol, 1.16% Sodium chloride |
| Accession#: | Q9Y265 |
| Alternative Names: | 49 kDa TATA box binding protein interacting protein/49 kDa TATA box-binding protein-interacting protein/49 kDa TBP interacting protein |
| Tag: | His |
| Amino Acid Sequence: | MGSSHHHHHHSSGLVPRGSHMKIEEVKSTTKTQRIASHSHVKGLGLDESG LAKQAASGLVGQENAREACGVIVELIKSKKMAGRAVLLAGPPGTGKTALA LAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAIGLRIKETKEV YEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHK KKEIIQDVTLHDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEIN KVVNKYIDQGIAELVPGVLFVDEVHMLDIECFTYLHRALESSIAPIVIFA SNRGNCVIRGTEDITSPHGIPLDLLDRVMIIRTMLYTPQEMKQIIKIRAQ TEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKINGKDSIEKEHV EEISELFYDAKSSAKILADQQDKYMK |
| Sequence Similarities: | Belongs to the ruvB family. |
| Expression System: | E. coli |
| Protein Length: | Full length protein; 1 to 456 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0014 | TIP60 Polyclonal Antibody | Inquiry |
| EAb-0015 | TIP60 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1664 | TRIM24 (TIF1), GST-tag | Inquiry |
| PE-1667 | TRIM24 (TIF1), His-tag | Inquiry |
| PE-1887 | TIP60 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| TIAL1 | TIEG1 | TIF1 | TIGD4 |
| TIGD5 | TIP49A | TIP49B | TIP60 |
| TIS11D | |||
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