| Cat.No.: | PE-2050 |
| Product Name: | Recombinant human KDM3A / JHDM2A protein |
| Background: | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. |
| Applications: | SDS-PAGE; Functional Studies |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 148 kDa including tags |
| Purity: | >27 % SDS-PAGE |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.71% Tris HCl, 0.72% Sodium chloride, 0.02% Potassium chloride, 10% Glycerol. Contains 90ng/ml DDDDK peptide |
| Accession#: | Q9Y4C1 |
| Alternative Names: | DKFZp686A24246/DKFZp686P07111/JHDM2A |
| Tag: | DDDDK |
| Amino Acid Sequence: | VLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAV SHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKS PEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQ DVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLD PSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTC GNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEIL LGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLN TKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQEN RLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVSN APEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSN NKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRL DSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIG LWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAW KRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAY KTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANC PCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGE AASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIK CLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLK NTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRL LCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGE QEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEPMVLKLKDWPPG EDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMY NAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLKTIQ DGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENP ADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQV HNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIY HAVKDAVAMLKASESSFGKP |
| Sequence Similarities: | Belongs to the JHDM2 histone demethylase family.Contains 1 JmjC domain. |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | Full length protein; 2 to 1321 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| CL-0087 | Human KDM1A Knockout Cell Line 10bp deletion | Inquiry |
| CL-0088 | Human KDM1B Knockout Cell Line 13bp deletion | Inquiry |
| CL-0089 | Human KDM2B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JHDM1A | JHDM1B | JHDM1D | JHDM2A |
| JHDM3A | KDM1 | KDM1A | KDM1B |
| KDM2 | KDM2A | KDM2B | KDM3A |
| KDM3B | KDM4 | KDM4A | KDM4B |
| KDM4C | KDM4D | KDM4E | KDM5 More > |
| KDM5A | KDM5B | KDM5C | KDM5D |
| KDM6A | KDM6B | KDM6C | KDM7 |
| KDM7A | KDM7B | KDM8 | |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
