| Cat.No.: | PE-2034 |
| Product Name: | RIZ1 Protein, Human, Recombinant |
| Product Overview: | N-terminal segment of human PRDM2 (NP_036363.2) (Met 1-Ala 200), containing the SET domian, with two additonal amino acids (Gly & Pro) at the N-terminus. |
| Background: | PR domain containing 2, with ZNF domain (PRDM2), also known as zinc finger protein RIZ, is a member of histone methyltransferase (HMT) class enzymes that methylate lysine residues of histones or proteins. HMTs contain a conserved catalytic core termed the SET domain, which shares sequence homology with an independently described sequence motif, the PR domain. PRDM2 contains 8 C2H2-type zinc fingers and a distinct SET domain, and is highly expressed in retinoblastoma cell lines and in brain tumors, as well as in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. PRDM2 is a S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3, and is identified as a tumor suppressor. It is reported that intact PR( SET) sequence is required for tumor suppression functions, mutations in the PR domain caused activity reduction in human cancers. Also, S-adenosylhomocysteine or methyl donor deficiency inhibits RIZ1 and other H3 lysine 9 methylation activities. PRDM2 may also function as a DNA-binding transcription factor. It Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and act as a transcriptional activator. In addition, PRDM2 (RIZ) is able to binds to the retinoblastoma protein (RB) and also Interacts with GATA3. |
| Applications: | ELISA; Western Blot , Enzyme activity assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | The recombinant human PRDM2 consists of 202 amino acids and predicts a molecular mass of 23 kDa. It migrates as an approximately 26 kDa band in SDS-PAGE under reducing conditions. |
| Purity: | > 96 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile 20mM Tris, 150mM NaCl, 0.5mM DTT, 0.5mM GSH, pH 8.01. |
| Accession#: | NP_036363.2 |
| Alternative Names: | HUMHOXY1 Protein, Human; KMT8 Protein, Human; MTB-ZF Protein, Human; RIZ Protein, Human; RIZ1 Protein, Human; RIZ2 Protein, Human |
| Expression System: | E. coli |
| Common Name: | PR domain containing 2, with ZNF domain |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0119 | Human RING1 Knockout Cell Line 1bp deletion | Inquiry |
| CL-0401 | Human RIF1 Knockout Cell Line 37bp insertion | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0178 | Human RIG-I/DDX58 peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-1750 | RING1 Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1892 | RIZ1 (human recombinant) | Inquiry |
| Related Gene / Proteins | |||
| RIF1 | RIG-I | RING1 | RING1B |
| RIZ1 | |||
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