| Cat.No.: | PE-2025 |
| Product Name: | PR-Set7 Protein, Human, Recombinant |
| Product Overview: | Human SETD8 (NP_065115.3) (Lys 195-His 352) with two additional amino acids (Gly & Pro) at the N-terminus. |
| Background: | KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K2 for methylation, has been implicated in multiple biological processes.Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a regulator for lipid metabolism in papillary thyroid carcinoma. |
| Applications: | ELISA; Western Blot , Enzyme activity assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | The recombinant human SETD8 comprises 160 amino acids and has a predicted molecular mass of 18.2 kDa. It migrates as an approximately 18 kDa band in SDS-PAGE under reducing conditions as predicted. |
| Purity: | > 98 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile 20mM Tris, 100mM NaCl, pH 8.01. |
| Accession#: | NP_065115.3 |
| Alternative Names: | KMT5A Protein, Human; PR-Set7 Protein, Human; SET07 Protein, Human; SET8 Protein, Human |
| Expression System: | E. coli |
| Common Name: | SET domain containing (lysine methyltransferase) 8 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
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