| Cat.No.: | PE-2013 |
| Product Name: | c-MET Protein, Human, Recombinant (His & Fc Tag) |
| Product Overview: | Extracellular domain (Met 1-Thr 932) of human c-Met (NP_000236) fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Background: | Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer. |
| Applications: | ELISA; Western Blot , Enzyme activity assay |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | The mature recombinant human c-Met/Fc is a disulfide-linked tetramer composed of two proteolytically cleaved α and β subunits. Each α and β together with the C-terminal Fc tag consists of 1155 amino acids and has a predicted molecular mass of 129.5 (α =32.5 + Fc tagged β=97) kDa. The rh c-MET/Fc heterodimer thus migrates with apparent molecular mass of approximately 45 kDa and 120 kDa respectively in SDS-PAGE under reducing conditions due to glycosylation. |
| Purity: | > 95 % as determined by SDS-PAGE |
| Species: | Human |
| Formulation: | Lyophilized from sterile PBS, pH 7.41. |
| Accession#: | NP_000236 |
| Alternative Names: | AUTS9 Protein, Human; c-Met Protein, Human; DFNB97 Protein, Human; HGFR Protein, Human; RCCP2 Protein, Human |
| Tag: | His & Fc |
| Endotoxin: | < 1.0 EU per μg of the protein as determined by the LAL method |
| Expression System: | HEK293 |
| Common Name: | MET proto-oncogene, receptor tyrosine kinase |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0018 | Danusertib (PHA-739358) | Inquiry |
| ◆ Antibodies | ||
| EAb-1913 | c-Myc Polyclonal Antibody (65 kDa form) | Inquiry |
| EAb-1914 | c-Myc Monoclonal Antibody | Inquiry |
| EAb-1941 | c-Jun Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1983 | C-jun Protein | Inquiry |
| Related Gene / Proteins | |||
| c-Fos | c-Jun | c-MET | c-Myc |
| c-RET | |||
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