| Cat.No.: | PE-1901 |
| Product Name: | PRMT4 (human recombinant) |
| Description: | Protein arginine methyltransferases (PRMT) are a family of enzymes with highly conserved catalytic domains that catalyze the transfer of a methyl group from S-adenosyl-L-methionine to a specific arginine residue in a target protein. PRMT4, also known as coactivator-associated arginine methyltransferase 1 (CARM1), is a type-1 PRMT, catalyzing ω-NG-monomethylarginine (MMA) and ω-NG,NG-dimethylarginine (aDMA) on histone H3, Arg-17 and Arg-26. PRMT4/CARM1 acts as a transcriptional coactivator by binding the p160 coactivator complex (SRC-1, GRIP1/TIF2, and pCIP/RAC3/ACTR/AIB1/TRAM1) thereby enhancing nuclear receptor function. PRMT4/CARM1 activity is inhibited by phosphorylation at Ser217, which prevents binding of S-adenosylmethionine. PRMT4 is ubiquitously expressed and is thought to play an important role in hormone mediated transcriptional regulation and lipid metabolism. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 92.6 kDa |
| Purity: | ≥70% |
| Species: | human |
| Formulation: | 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Accession#: | Q86X55 |
| Alternative Names: | CARM1;Coactivator-associated Arginine Methyltransferase 1;Protein Arginine Methyltransferase 4 |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 2-608 (full-length) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Synthetic Peptides | ||
| SP-0008 | PRMT4 peptide substrate, Biotin-labeled | Inquiry |
| ◆ Cell Lines | ||
| CL-0050 | Human CARM1 Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0123 | Ellagic acid | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0134 | Recombinant Human CARM1 293 Cell Lysate | Inquiry |
| EL-0148 | Recombinant Human CAMTA2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| CABIN1 | CAF1 | CAMKIV | CAMTA2 |
| CAPNS2 | CARHSP1 | CARM1 | CASC3 |
| CASP | CASP1 | CASP3 | |
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