| Cat.No.: | PE-1894 |
| Product Name: | SMYD3 (human recombinant) |
| Description: | The SET and MYND domain (SMYD) containing family of proteins is made up of SMYDs 1-5, all of which have a distinctive SET domain that is split by a MYND domain. The SET domain is responsible for methyltransferase activity, whereas the MYND domain is a zinc finger that facilitates protein-protein interactions with specific proline-rich sequences. The SMYDs also contain a novel C-terminal domain (CTD) that helps to regulate histone methylation. SMYD activity and specificity can be significantly stimulated by binding of heat shock protein 90 (Hsp90), which is thought to cause the CTD to swing out, thereby fully exposing the active site. SMYD3 was shown to be overexpressed in several different cancers, such as breast, colorectal, and liver cancer. Studies suggest that cancerous cells may express full-length and a more active cleaved SMYD3 that lacks the first 34 amino acids at the N-terminus. The N-terminus of full-length SMYD3 interacts with Hsp90α and increases its activity, suggesting that the N-terminal region is involved in regulating methyltransferase activity. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 58.5 kDa |
| Purity: | ≥60% |
| Species: | human |
| Formulation: | 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride, and 20% glycerol |
| Accession#: | Q9H7B4 |
| Alternative Names: | KMT3E;SET and MYND domain-containing protein 3 |
| Tag: | His & SUMO |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 More > |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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