SETD2 (human recombinant)

Cat.No.:	PE-1891
Product Name:	SETD2 (human recombinant)
Description:	SETD2 is a histone methyltransferase that catalyzes the trimethylation of Histone H3 on lysine 36 (H3K36). SETD2 knockdown in mouse fibroblast cells demonstrates unaltered mono- and di-methylation but an impairment of trimethylation at H3K36 suggesting primarily trimethylase activity. However, it remains to be elucidated whether this methyltransferase activity is processive or non-processive. The WW domain of SETD2 has been shown to interact with hyperphosphorylated RNA polymerase II, indicating a broad role in transcriptional regulation. Evidence has also been found indicating SETD2 can automethylate itself, possibly influencing its methyltransferase activity. SETD2 interacts with huntingtin, the protein implicated in Huntington’s Disease, and may contribute to the progression of the disease.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	33.7 kDa
Purity:	≥95%
Species:	human
Formulation:	50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Accession#:	Q9BYW2
Alternative Names:	Huntington Interacting Protein B;HYPB;KMT3A;p231HBP
Tag:	His
Expression System:	E. coli
Protein Length:	1435-1711 (N- and C- terminal truncations)
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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