TIP60 (human recombinant)

Cat.No.:	PE-1887
Product Name:	TIP60 (human recombinant)
Description:	TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase. As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription. In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone γH2AX allows formation of the γH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of β-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer’s disease pathogenesis.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	60.3 kDa
Purity:	≥70%
Species:	human
Formulation:	20 mM Tris, pH 7.5, containing 10% glycerol
Accession#:	Q92993
Alternative Names:	cPLA(2) Interacting Protein;Esa1;HIV-1 Tat Interacting Protein 60 kDa;Hs.6364;HTATIP;KAT5;PLIP
Tag:	His
Expression System:	Sf21 Insect Cells
Protein Length:	2-513 (Full length, Isoform 2)
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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