| Cat.No.: | PE-1881 |
| Product Name: | MLL1/WARD Complex (human recombinant) |
| Description: | The MLL complex methylates histone 3 at lysine 4 (H3K4) to upregulate transcription. MLL1 is the catalytic subunit and contains the core components WDR5, Ash2L, and RbBP5 (MLL/WAR complex). MLL1 alone exhibits a low basal methyltransferase activity, but is enhanced 300-fold by the addition of the WAR components. A further 2-fold activation has been reported with the addition of DPY-30 (MLL/WARD complex). The MLL core complex colocalizes with RNA Polymerase II on chromosomes and is involved in the transition of paused Pol II to actively-transcribing Pol II. Misregulation of MLL1 by fusion of its non-catalytic N-terminus to any of >50 other proteins leads to leukemia, possibly due to release of paused Pol II at developmentally important sites such as the Hox family of genes. Wild-type MLL1 is targeted to Hox genes through interactions with menin, and is thus important for proper development. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | ~200.1 kDa |
| Purity: | ≥90% |
| Species: | human |
| Formulation: | Tubes containing sufficient protein to form an equimolar ratio of the MLL1/WARD complex |
| Alternative Names: | KMT2A;Mixed-Lineage Leukemia-1;MLL Core Complex |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0170 | MI-3 | Inquiry |
| BSM-0187 | OICR-9429 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0172 | Human KMT2C / MLL3 peptide | Inquiry |
| ◆ Research Kits | ||
| EKIT-0285 | MLL1 Complex Chemiluminescent Assay Kit | Inquiry |
| EKIT-0286 | MLL1 SAM-Screener Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| MLH1 | MLL | mll1 | MLL2 |
| MLL3 | MLL4 | MLL5 | MLLT1 |
| MLLT3 | WAR | WARD | |
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