| Cat.No.: | PE-1871 |
| Product Name: | DPY-30 (human recombinant) |
| Description: | DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L. In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development. DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer. Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold increase in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 11.2 kDa |
| Purity: | ≥95% |
| Species: | human |
| Formulation: | 50 mM Tris, pH 8.0, 100 mM sodium chloride, and 20% glycerol |
| Accession#: | Q9C005 |
| Alternative Names: | DPY-30-like protein;hDPY-30;SAF19 |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0099 | Human DPEP1 Knockout Cell Line | Inquiry |
| CL-0102 | Human DPEP3 Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-0974 | DPY30 Polyclonal Antibody, HRP Conjugated | Inquiry |
| EAb-0975 | DPY30 Polyclonal Antibody, FITC Conjugated | Inquiry |
| EAb-0976 | DPY30 Polyclonal Antibody, Biotin Conjugated | Inquiry |
| Related Gene / Proteins | |||
| DP1 | DP2 | DPEP1 | DPEP3 |
| DPF3 | DPY30 | ||
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