PRDM9 (human recombinant)

Cat.No.:	PE-1870
Product Name:	PRDM9 (human recombinant)
Description:	Recombination hotspots are small segments of the genome where genetic information gets shuffled at an elevated rate during meiosis. PR domain zinc finger protein 9 or PRDM9 is a histone methyltransferase that binds specifically to these hotspots catalyzing trimethylation of H3K4 in nucleosomes near its binding site, thus initiating genetic recombination by recruiting recombination initiation machinery. PRDM9 contains an amino terminal PR/SET domain for HTMase activity and a C-terminal tandem array of twelve C2-H2 zinc-fingers. The zinc fingers of PRDM9 are thought to bind with high affinity to a 13-mer hotspot motif in DNA, which promotes double strand break formation in the area around the binding site. PRDM9 is unique in that its activity is tissue specific, only expressing in germ cells during meiosis.
Storage:	Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:	60.5 kDa
Species:	human
Formulation:	50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride and 20% glycerol
Accession#:	Q9NQV7
Alternative Names:	Meisetz;MSBP3;PFM6;PR Domain-containing Protein 9;ZNF899
Tag:	His
Expression System:	E. coli
Protein Length:	2-511 (C-terminal truncation)
Warning:	This product is for research use only. Not for use in diagnostic or therapeutic procedures.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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