| Cat.No.: | PE-1854 |
| Product Name: | NSD3 (human recombinant) |
| Description: | The nuclear receptor SET domain-containing (NSD) family of histone lysine methyltransferases are important enzymes responsible for maintaining chromatin integrity. The NSD family consists of three members NSD1, NSD2 (WHSC1 and MMSET), and NSD3 (WHSC1-like). NSD3 has been mapped to chromosome 8p12 and found to be amplified in several tumor cell lines and primary breast cancers. Chromosomal translocation leading to chimeric NUP98 and NSD3 gene fusion has been documented in a patient with acute myeloid leukemia. The BET (bromodomains and extraterminal) domain protein Brd4 has been shown to recruit NSD3 to target genes through the interaction with the Brd4 extraterminal domain. Knockdown of either Brd4 or NSD3 was shown to reduce histone H3K36 trimethylation levels suggesting that Brd4/NSD3 are involved in regulating H3K36 methylation levels. X-ray crystallography and mutagenesis data shows that the fifth plant homeodomain and the adjacent Cys-His-rich region of NSD3 recognizes unmodified H3K4 and trimethylated H3K9. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 61.2 kDa |
| Purity: | ≥90% (by SDS-PAGE) |
| Species: | human |
| Formulation: | 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Alternative Names: | Histone-lysine N-methyltransferase NSD3;WHSC1-like protein 1 |
| Tag: | GST |
| Expression System: | E. coli |
| Protein Length: | 1,021-1,322 (N- and C-terminal truncation) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0494 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0498 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0502 | NSD2 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | |
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