| Cat.No.: | PE-1852 |
| Product Name: | ASH1L bromodomain (human recombinant) |
| Description: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain. These domains function in linking protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. ASH1L is the mammalian homolog of the Drosophila protein Absent, small, or homeotic disc 1 (Ash1), a trithorax group histone methyltransferase involved in gene activation. ASH1L contains an associated with SET domain, a SET domain, a post-SET domain, a bromodomain, a bromoadjacent homology domain, and a plant homeodomain finger. ASH1L regulates mammalian Hox gene expression, which plays an important role in haematopoietic development in mammals. ASH1L has been reported to methylate histone H3 at lysine 4 (H3K4) and H3K36. This protein product contains the bromodomain region of ASH1L. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 42 kDa |
| Purity: | ≥90% |
| Species: | human |
| Formulation: | 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Accession#: | Q9NR48 |
| Alternative Names: | Absent Small and Homeotic Disks Protein 1 homolog;ASH1-like protein;Histone-lysine N-Methyltransferase ASH1L;Lysine N-Methyltransferase 2H |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0018 | Human ASH1L Knockout Cell Line 53bp deletion | Inquiry |
| CL-0019 | Human ASXL2 Knockout Cell Line 1bp insertion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0162 | Recombinant Human ASH2L 293 Cell Lysate | Inquiry |
| EL-0173 | Recombinant Human ASF1A 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0168 | ASH2 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ASB10 | ASB11 | ASB13 | ASB6 |
| ASB7 | ASB8 | ASB9 | ASF1 |
| ASH1L | ASH2 | ASXL2 | |
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