| Cat.No.: | PE-1844 |
| Product Name: | TRIM33 PHD and bromodomain (human recombinant) |
| Description: | TRIM33 (TIF1-γ) is a multi-domain regulator of transcription. It contains a RING domain with E3 ubiquitin ligase activity, two B-boxes, a coiled-coil domain, a PHD domain, and a bromodomain. TRIM33 is targeted to DNA by its tandem PHD and bromodomain which bind histone 3 at trimethylated lysine 9 (H3K9me3) and acetylated lysine 18 (H3K18ac), respectively. TRIM33 represses TGF-β signaling by sequestering SMAD2/3, and by ubiquitinating SMAD4. The TRIM33-SMAD2/3 complex upregulates transcription at sites of H3K9 trimethylation. During the DNA damage response, TRIM33 targets Amplified in Liver Cancer 1 (ALC1) to sites of DNA damage. Deletion of either the PHD or bromodomain of TRIM33 prevents localization of TRIM33 to sites of DNA damage. This protein product contains the PHD and bromodomains of TRIM33. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 51.4 kDa |
| Purity: | ≥80% |
| Species: | human |
| Formulation: | 50 mM TRIS, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Alternative Names: | Ectodermin Homolog;E3 Ubiquitin-protein Ligase TRIM33;RFG7;TIF1-γ;Transcriptional Intermediary Factor 1-γ;Tripartite Motif Containing 33 |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0018 | Danusertib (PHA-739358) | Inquiry |
| BSM-0021 | PF-03814735 | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0107 | Recombinant Human TRIM68 293 Cell Lysate | Inquiry |
| EL-0109 | Recombinant Human TRIP4 Lysate | Inquiry |
| EL-0115 | Recombinant Human TRIM24 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| TRA2A | TRAF4 | TRAF5 | TRAF6 |
| TRAK2 | TRBP | TRDMT1 | TREX1 |
| TRF2 | TRIM11 | TRIM13 | TRIM16 |
| TRIM17 | TRIM2 | TRIM21 | trim24 |
| TRIM26 | TRIM28 | TRIM3 | TRIM33 More > |
| TRIM34 | TRIM35 | TRIM36 | TRIM37 |
| TRIM38 | TRIM39 | TRIM4 | TRIM5 |
| TRIM55 | TRIM6 | TRIM63 | TRIM66 |
| TRIM68 | TRIM8 | TRIM9 | TRIML1 |
| TRIP4 | Tristetraprolin | TRIT1 | TrkA |
| TRMT2A | TRMT44 | TRMT5 | TRMT6 |
| TROVE2 | TRUB2 | TRX1 | TRβ1 |
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