| Cat.No.: | PE-1843 |
| Product Name: | CHD1 chromodomains (human recombinant) |
| Description: | Chromodomain helicase DNA binding protein 1 (CHD1) is an ATP-dependent chromatin remodeler that recognizes di- or tri-methylated histone H3 at lysine 4 (H3K4me2/3). CHD1 binds to H3K4me3 and is a component of pre-initiation complexes that also contain Mediator. The two chromodomains of CHD1 are necessary for recognition of H3K4me3. Knockdown of CHD1 by shRNA leads to an increase in the markers of heterochromatin. In embryonic stem cells, shRNA against CHD1 leads to decreased proliferation and increased expression of neural markers. Spontaneous deletion in prostate cells causes morphological changes correlated with invasiveness. Finally, deletion of CHD1 in yeast results in decreased levels of histone H2B monoubiquitination. This protein product contains the two chromodomains of CHD1. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 49.3 kDa |
| Purity: | ≥95% |
| Species: | human |
| Formulation: | 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Alternative Names: | ATP-Dependent Helicase CHD1;Chromodomain Helicase DNA Binding Protein 1 |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0147 | Recombinant Human CHAF1A 293 Cell Lysate | Inquiry |
| EL-0167 | Recombinant Human CHAF1B 293 Cell Lysate | Inquiry |
| EL-0211 | Recombinant Human CHD2 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0180 | Mouse Chd7 peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-0199 | CHRDL1 Monoclonal Antibody (3H1-F6-A10) | Inquiry |
| Related Gene / Proteins | |||
| CHAF1A | CHAF1B | CHD1 | CHD2 |
| CHD3 | CHD4 | CHD5 | Chd7 |
| CHD8 | CHD9 | CHEK2 | CHRAC1 |
| CHRDL1 | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
