| Cat.No.: | PE-1842 |
| Product Name: | CHD2 chromodomains (human recombinant) |
| Description: | Chromodomain helicase DNA binding protein 2 (CHD2) is an ATP-dependent chromatin remodeling protein. It contains two N-terminal chromodomains, an SNF2-like helicase domain, and a C-terminal DNA-binding domain. The two N-terminal chromodomains have a 30-fold lower affinity for methylated histone H3K4 than the chromodomains of CHD1. CHD2 co-localizes with MyoD and histone H3, and knockdown of CHD2 prevents deposition of H3. at differentiation-dependent genes. Deletion of the CHD2 chromodomains prevents co-localization with H3. Loss or mutation of CHD2 has been implicated in epilepsy. Deletion of the DNA-binding domain of CHD2 in mice is homozygous lethal. Mice heterozygous for this deletion suffer decreased size, decreased viability, and abnormalities of the liver, heart, kidneys, and spleen. Reduced levels of CHD2 expression lead to lymphomas and reduced clearance of γH2AX foci following DNA damage. This protein product contains the two chromodomains of CHD2. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 50.2 kDa |
| Purity: | ≥90% |
| Species: | human |
| Formulation: | 50 mM Tris, pH 8.0, containing 150 mM sodium chloride and 20% glycerol |
| Alternative Names: | ATP-Dependent Helicase CHD2;Chromodomain Helicase DNA Binding Protein 2 |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0147 | Recombinant Human CHAF1A 293 Cell Lysate | Inquiry |
| EL-0167 | Recombinant Human CHAF1B 293 Cell Lysate | Inquiry |
| EL-0211 | Recombinant Human CHD2 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0180 | Mouse Chd7 peptide | Inquiry |
| ◆ Antibodies | ||
| EAb-0199 | CHRDL1 Monoclonal Antibody (3H1-F6-A10) | Inquiry |
| Related Gene / Proteins | |||
| CHAF1A | CHAF1B | CHD1 | CHD2 |
| CHD3 | CHD4 | CHD5 | Chd7 |
| CHD8 | CHD9 | CHEK2 | CHRAC1 |
| CHRDL1 | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
