| Cat.No.: | PE-1834 |
| Product Name: | SMYD2 (human recombinant) |
| Description: | The SET and MYND domain (SMYD) containing family of proteins is made up of SMYDs 1-5, all of which have a distinctive SET domain that is split by a MYND domain. The SET domain is responsible for methyltransferase activity, whereas the MYND domain is a zinc finger that facilitates protein-protein interactions with specific proline-rich sequences. The SMYDs also contain a novel C-terminal domain (CTD) that helps to regulate histone methylation. SMYD activity and specificity can be significantly stimulated by binding of heat shock protein 90 (Hsp90), which is thought to cause the CTD to swing out, thereby fully exposing the active site. SMYD2 is known to methylate histone H3 at lysine 36 (H3K36). In the presense of HSP90α the methyltransferase activity is enhanced at lysine 4 (H3K4). Further, SMYD2 has been shown to monomethylate p53 lysine 370 causing a repression of p53-mediated transcriptional activation. Downregulation of SMYD2 in cells may promote p53 dependent apoptosis. SMYD2- mediated methylation of the tumor suppressor retinoblastoma protein at lysine 860 (Rb Lys-860) has been demonstrated, however, the biological function of this post-translational modification is unclear. Rb Lys-860 methylation may be involved in the interaction with L3MBTL1, a chromatin compaction factor in triple malignant brain tumor. A correlation between high levels of SMYD2 and lower survival rates has been reported for patients with esophageal squamous cell carcinoma. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 62.7 kDa |
| Purity: | ≥80% |
| Species: | human |
| Formulation: | 50 mM Tris-HCl, pH 8.5, containing 400 mM sodium chloride, 1 mM DTT, and 20% glycerol |
| Accession#: | Q9NRG4 |
| Alternative Names: | Histone methyltransferase SMYD2;HSKM-B;KMT3C;Lysine N-methyltransferase 3C;SET and MYND domain-containing protein 2 |
| Tag: | His & SUMO |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0019 | SMARCA4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0063 | Recombinant Human SMARCC2 293 Cell Lysate | Inquiry |
| EL-0064 | Recombinant Human SMARCB1 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0080 | AZ-505 ditrifluoroacetate | Inquiry |
| ◆ Research Kits | ||
| EKIT-0120 | BRG1 bromodomain TR-FRET Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| SMAD3 | SMAD4 | SMARCA1 | SMARCA2 |
| SMARCA4 | SMARCA5 | SMARCA6 | SMARCAD1 |
| SMARCAL1 | SMARCB1 | SMARCC1 | SMARCC2 |
| SMARCD1 | SMARCD2 | SMARCD3 | SMARCE1 |
| SMC1-α | SMC3 | SMC4 | SMCHD1 More > |
| SMCX | SMN | SMN1 | SMN2 |
| SMOC2 | SMRT | SMT3 | SMUG1 |
| SMURF2 | SMYD1 | SMYD2 | SMYD2B |
| SMYD3 | SMYD4 | SMYD5 | |
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