Vegetarian diet is widely praised for its benefits in reducing cholesterol, heart disease risk, and preventing type 2 diabetes, but researchers believe that this special diet may also have a cost. Recently, a research team from the University of Georgia revealed the important role of genetic factors in determining whether a vegetarian diet is suitable for individuals, providing a solid scientific basis for the development of personalized nutrition plans….
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A New Strategy For Tumor Growth Inhibition: BCL9/BCL9L Targeted Therapy And cDC1 Activation
Zhu Di and Wang Mingwei from Fudan University jointly published a research paper titled “Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration” in Signal Transmission and Targeted Therapy. This study indicates that targeting BCL9/BCL9L enhances antigen presentation by stimulating cDC1 activation and infiltration into tumors. Knockout mice with novel inhibitors hsBCL9z96 or BCL9/BCL9L can significantly delay tumor growth and promote anti-tumor…
New Research Has Found Biomarkers for Predicting the Risk of Human Cell Aging and Death
As cells age, they experience aging, a state where they stop growing but continue to release inflammatory and tissue-degrading molecules. When a person is young, the immune system will respond by eliminating aging cells, commonly known as “zombie cells”. However, zombie cells will continue to exist and lead to a series of age-related health problems and diseases. In a new study, researchers from the Mayo Clinic in the United…
In Situ PEG Modification of CAR-T Cells Can Alleviate Cytokine Release Syndrome and Neurotoxicity
In recent years, cancer researchers have cheered the arrival of chimeric antigen receptor (CAR) T-cell therapy, which has achieved encouraging results and changed the treatment methods of various cancers. CAR-T cell therapy targets cancer cells through genetically modified patients’ T cells, thereby achieving a significant cure rate for previously incurable cancers. Currently, six CAR-T cell therapies have been approved by the US Food and Drug Administration (FDA), and several…
Scientists have found 32 proteins related to dementia in the blood of middle-aged people based on 25 years of data!
Genome-wide association studies on Alzheimer’s disease (AD) have shown that its biological process is very complex and not limited to the accumulation of β Amyloid protein (Aβ）and tau protein. Systemic factors and biological processes outside the central nervous system may also affect the risk of dementia and AD. Proteins, as systemic circulating factors, may be driving factors for complex central nervous system diseases, and researchers have been searching for…
By Activating Oct4, Premature Aging Mouse Cells Can Recover Their Vitality
Aging seems to be an irresistible natural law, and at the same time, how to “fight aging and achieve immortality” has become an eternal research topic. Nowadays, thanks to the rapid development of biotechnology, research on anti-aging has become increasingly popular. In 2006, the team of Shinya Yamanaka of Kyoto University in Japan first reported related research on induced pluripotent stem cells (iPSC). They found that by introducing four…
Restoring lost epigenetic information can make aging mammals rejuvenate
An international study lasting for 13 years has shown for the first time that the degradation of the way DNA is assembled and regulated – the so-called epigenetics – can drive the aging of organisms, and has nothing to do with the change of the genetic code itself. This study shows that the destruction of epigenetic information leads to the aging of mice, and the restoration of the integrity of…
CAR-T cell therapy is expected to eliminate residual tumor cells after solid tumor surgery
In a new preclinical study, researchers from the Perelman School of Medicine at the University of Pennsylvania found that as a method of reprogramming patients’ autoimmune cells to attack their blood cancer, CAR-T cell therapy may improve the effectiveness of surgical treatment of solid tumors. The relevant research results were published in the journal Science Advances, and the title of the paper was “Chiric antigen receiver T cells as adjuvant-therapy…
Occluding the ACE2 receptor, renders all mutants incapable of infection!
With successive waves of uncapping, enhancing disease resistance has become one of the most important things at present. Vaccines are the most effective medicines to fight the coronavirus at the moment, and intensified vaccination is also a more desirable method. However, the Omicron virus strain has evolved an extreme ability to infect, and it is not realistic to hope for a vaccine to eliminate the infection. On the other…
Research Reveals Cross-species Transmission of Primate Lentivirus
Humans continue to be threatened by viral diseases such as Ebola, Zika, and Coronavirus. Such emerging/re-emerging virus outbreaks may be caused by cross-species viruses transmitted from wild animals to humans. In order to achieve cross-species transmission, the new host must be exposed to the virus in the old host. Next, the virus acquires certain mutations that may be beneficial for replication in the new host. Finally, by continuing to…