Gene expression is the core mechanism for maintaining life activities, and translation initiation is an important link in it. The efficiency and accuracy of the translation initiation process directly affect protein synthesis, which is crucial for the normal function of cells. In eukaryotes, most mRNA molecules rely on the 7-methylguanosine cap (mRNA cap) located at the 5′ end to initiate translation. However, the specific molecular mechanism of this critical step…

Paxlovid was launched in December 2021. As an effective antiviral drug, it is an effective antiviral drug. But like many antiviral drugs before it, scientists know that at some point, paroxetine may lose some efficacy due to resistance.   Now, researchers dedicated to addressing such emerging threats have identified a novel approach for treating SARS-CoV-2 infection in a new study. They conducted a conceptual validation of a new class of…

Extending lifespan by eliminating aging inflammatory cells is a tempting idea, but scientists in the field of anti-aging suspect that it is too simplistic. Now, in a new study, researchers from the University of Connecticut have confirmed that as age increases, inflammatory cells become diverse, some of which play important roles in the body.   The relevant research results were published online in the journal Nature Aging, with the title…

Cells in the immune system do not always fight. They often rest and wait for threats such as viruses or bacteria. When these threats arise, these cells activate to protect the body. The delicate balance between rest and activation is crucial for human health—immune cells must be prepared to activate to resist threats, but if they become too active, it may lead to autoimmune diseases. But what controls this important…