| Cat# | Product Name | Price |
|---|---|---|
| Kit-0365 | Gamma Glutamyl Transferase (GGT) Activity Colorimetric Assay Kit | Inquiry |
| Kit-0366 | Gamma Glutamyl Transferase (GGT) Activity Fluorometric Assay Kit | Inquiry |
| Kit-0367 | GGT Activity Colorimetric Assay Kit | Inquiry |
| Kit-0368 | GGT Activity Fluorometric Assay Kit | Inquiry |
GGT, i.e γ- Gamma glutamyltransferase is an important enzyme in the human body, and its catalyst and functional regulation form the balance of certain metabolic reactions in the human body. GGT is widely distributed in the human liver and biliary system, and also exists in other organs such as the kidney, pancreas, and heart. The main function of GGT is to participate in the metabolism of bile acids, small peptides, amides, and amyloids, as well as participate in functions such as cell apoptosis and immune response in the body.
The biological activity of GGT is mainly reflected by enzyme catalysis, that is, it catalyzes the conversion reaction of other compounds. When certain toxins such as alcohol and drugs enter the human body, GGT metabolizes them into more easily excreted forms. At the same time, the polymorphism of the GGTA1 gene promoter region can also affect certain biological functions of GGT. Some studies have shown that excessive activity of GGT is characterized by high enzyme concentrations, which can be associated with the occurrence and treatment of liver diseases, postoperative recovery, tumors, and other diseases.
In clinical medicine, GGT is an important marker of liver function, which can be used as a diagnostic and monitoring indicator for liver and biliary system diseases, as well as for macroscopic evaluation of the intake and metabolism of toxic substances in the body. Therefore, people attach great importance to the method of measuring GGT enzyme activity.
In modern medicine, there are two commonly used methods for detecting GGTA1 enzyme activity: one is to measure the concentration of GGT enzyme in serum; The other is the peptide GGTF-L modified by synthetic gamma glutamiyl-p-nitroanilide (GG-PNP) or natural acetylcysteine（ γ- Glutamyl phenylalanine L lucine and other substrates are used as substrates, and GGT catalyzes the reaction. The conversion rate of the substrate is measured as the method for measuring GGT enzyme activity. The commonly used detection principle is to react with the substrate and antibody to generate an absorption peak, which is proportional to the degree of substrate transformation and represents the intensity of GGT activity. At the same time, before the experiment, it is necessary to confirm whether the tested sample has been diluted, whether the oscillation is sufficient, and whether the background value is comparable to the measured value of the regular sample. Routine calibration of the detection instrument should be carried out to ensure the accuracy of the measurement results.
In summary, the measurement methods and principles of GGT enzyme have been continuously updated and improved, providing clinicians with more accurate and reliable detection methods, as well as providing stronger guarantees for early diagnosis and timely treatment of diseases.
We are here to answer any question you may have