Product Overview :
Chloride Channel Assay Kit is used for the measurement of chloride channel activity.
Description :
Chloride channels have a variety of important physiological and cellular functions that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. Chloride channels represent valuable drug targets. A number of chronic disease states such as cystic fibrosis and Bartters syndrome are due to defects in chloride channel functions. However, the existing technologies for screening chloride channel modulators are a compromise between throughput, sensitivity and physiological relevance.
Usage :
For research use only (RUO)
Storage :
Keep in -20°CProtect from moisture and lightAvoid repeated freeze-thaw cycles
Kit Components :
Component A: Iodide Blue Sensor 50 mlComponent B: Iodide Sensor Enhancer (100X) 0.5 mlComponent C: ILoadingBuffer 100 mlComponent D: Cell Lysis Buffer (10X) 5 ml
Detection method :
Colorimetric
Compatible Sample Types :
Live Cells
Features & Benefits :
High Sensitivity: As low as 30 nM of iodide can be detected.Convenient: Formulated to have minimal hands-on time.Less toxicity: Ease of use with less toxicity than the classic Sandell and Kolthoff assay.Continuous: Continuous assay without a separation step.
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